01
Liver signaling
Intravenous microdoses reach circulation rapidly and are intended to recreate signals involved in healthy carbohydrate metabolism.
Physician-supervised metabolic care
MicroDose Infusion Treatments
A personalized infusion protocol designed to reproduce key metabolic signals involved in the way the liver processes energy.
- Provider-led
- Individualized
- Monitored in clinic
Care built around youYour history, medications and goals guide every treatment plan.
MDI
The treatment concept
Supporting more efficient cellular energy production
MicroDose Infusion (MDI) uses carefully controlled intravenous pulses of human regular insulin intended to mimic aspects of normal pancreatic insulin release. The protocol is designed to signal the liver during carbohydrate metabolism, a process connected with production of ATP—the energy cells use to perform their work.
Because insulin and glucose require precise medical management, MDI begins with a physician evaluation and is administered with ongoing monitoring by trained clinical staff.
MDI is an individualized medical therapy. Candidacy, expected benefit, frequency and duration are determined by the treating physician.
Why metabolism matters
A different lens on metabolic health
The protocol focuses on metabolic signaling and cellular energy—not simply a single laboratory number.
02
Cellular energy
Carbohydrate metabolism supports ATP production, which cells rely on for normal function, maintenance and repair.
03
Measured response
The care team monitors glucose and the patient's clinical response, then adjusts the plan according to current medical need.
What a visit may involve
Structured, supervised and tailored over time
A clinic visit commonly includes three approximately one-hour treatment cycles. The exact schedule can vary significantly by diagnosis, response and physician direction.
1
Clinical review
History, current medications, glucose trends and treatment goals are reviewed.
2
Preparation
Your team provides individualized food, medication and arrival instructions.
3
Infusion cycles
Treatment is administered in clinic with clinical observation and glucose monitoring.
4
Follow-through
Your response is reviewed and the next session is scheduled only as medically appropriate.
Conditions discussed in MDI care
Who may ask about MDI?
MDI has been explored for diabetes-related complications and other conditions with a metabolic component. A consultation is required to determine whether it is appropriate.
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Diabetes and metabolic dysfunctionIncluding concerns related to energy regulation, neuropathy or slow-healing wounds.
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Kidney or liver conditionsPatients with chronic disease require careful coordination with their established specialists.
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Fatigue and fibromyalgiaPersistent fatigue may have many causes and needs a complete medical assessment.
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Other metabolically influenced conditionsThe physician will evaluate the evidence, risks, alternatives and realistic goals for each patient.
Important: Inclusion here does not mean MDI is proven to diagnose, treat, cure or reverse every listed condition. Published evidence and regulatory status may differ by device, protocol and intended use. Results vary, and no outcome is guaranteed.
Common questions
What patients want to know
How is MDI different from a wearable insulin pump?
A wearable pump delivers insulin into tissue beneath the skin for ongoing diabetes management. MDI is an in-clinic protocol using timed intravenous microdoses under direct clinical supervision. They are not interchangeable therapies.
How long does a treatment visit take?
The source protocol describes three approximately one-hour sessions during a treatment visit. Your actual visit length, breaks and monitoring requirements will be explained by the clinical team.
How often are treatments scheduled?
Frequency is individualized. Some protocols begin with several sessions per week and taper over time; others use wider intervals. Only the treating physician can set the right schedule for you.
Should I change my medication or meals before treatment?
Never change insulin, diabetes medication, food intake or other prescriptions based only on general website information. New Hope Vitality will provide patient-specific written instructions after reviewing your medical history.
Do I continue seeing my current physicians?
Yes. MDI is not a substitute for primary or specialty care. Continue seeing your current clinicians and taking medications as prescribed unless your treating physician gives you specific instructions.
What results should I expect?
Response varies by patient, diagnosis, disease duration and overall health. The clinical team will discuss reasonable goals and how progress may be assessed. No specific improvement or timeline can be promised.
Physician leadership
Meet Dr. Everard Esteban
Board Certified • Family MedicineBoard Certified • Lifestyle Medicine
Dr. Esteban earned his Kinesiology/Pre-Medicine degree from UCLA, completed pathology fellowship studies at UC Irvine College of Medicine, received his MD in 1996 and completed the UCLA/Northridge Family Practice Residency Program in 1999.
After serving as a family physician with Bristol Park Medical Group, he practiced with Kaiser Permanente from 2001 through 2024. He is board certified in Family Medicine and in Lifestyle Medicine through the American Board of Lifestyle Medicine and the International Board of Lifestyle Medicine.
Learn before you decide
Get notified about the next MDI Physician Information Session
Meet the clinical team, hear how physician-supervised MDI works, and bring your questions. Share your contact information and we’ll send the date and attendance details when the next session is scheduled.
A thoughtful next step
Find out whether MDI fits your care plan
Begin with a no-pressure clinical conversation about your history, goals, potential risks, alternatives and realistic expectations.